Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24936702 | 0.92 | TDP1 (0.51) | CYSLTR2CYSLTR1LTA4HLMNAHRH2 | |
| SCHEMBL9127586 | 0.89 | CYSLTR2 (0.51) | CYSLTR2CYSLTR1BRD4FAAHLTA4H | |
| SCHEMBL9127593 | 0.89 | CYSLTR2 (0.51) | CYSLTR2CYSLTR1BRD4FAAHLTA4H | |
| SCHEMBL7334450 | 0.84 | HRH3 (0.57) | CYSLTR2CYSLTR1FAAHHRH2HRH1 | |
| SCHEMBL6937314 | 0.83 | MEN1 (0.62) | CYSLTR2CYSLTR1BRD4FAAHLTA4H | |
| SCHEMBL767042 | 0.83 | TDP1 (0.62) | CYSLTR2CYSLTR1FAAHLTA4HLMNA | |
| SCHEMBL7398657 | 0.82 | LMNA (0.50) | CYSLTR2CYSLTR1LTA4HLMNAMAPT | |
| SCHEMBL8981963 | 0.82 | BRD4 (0.56) | CYSLTR2CYSLTR1BRD4LTA4HHRH2 | |
| SCHEMBL3466988 | 0.82 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1BRD4FAAHLTA4H | |
| SCHEMBL30178403 | 0.82 | TBXAS1 (0.56) | CYSLTR2CYSLTR1FAAHLMNATBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294549-B1 | COMPOUNDS USEFUL FOR INHIBITING RESTENOSIS, ANGIOGENESIS, ATHEROSCLEROSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, INFLAMMATION OR TUMOR GROWTH. | MERCK & CO., INC. | 2001-09-25 | — | — | US | disclosed |
| US-5952306-A | INHIBITING THE BINDING OF FIBRINOGEN TO BLOOD PLATELETS AND INHIBITING THE AGGREGATION OF BLOOD PLATELETS; INHIBITING OSTEOCLAST CELLULAR ADHESION TO BONE SURFACES | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |