Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.40 |
| ▸ | GABRE | P78334 | 2/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68869 | 0.87 | MAPK1 (0.63) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL5700876 | 0.79 | KDM4E (0.61) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL990711 | 0.79 | MAPK1 (0.55) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL428719 | 0.78 | MAPK1 (0.53) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL1858691 | 0.78 | POLB (0.59) | MAPK1L3MBTL1ALDH1A1LMNACYP1A2 | |
| SCHEMBL13524601 | 0.76 | SIRT6 (0.67) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL64740 | 0.76 | SIRT6 (0.57) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL22119742 | 0.76 | MAPK1 (0.52) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL544241 | 0.76 | MAPK1 (0.52) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL31444432 | 0.76 | MAPK1 (0.52) | MAPK1KDM4EL3MBTL1LCKPCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |