Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990066 | 0.91 | NPC1 (0.47) | NPC1RAB9AKMT2AGAATSHR | |
| SCHEMBL7977681 | 0.87 | RAB9A (0.54) | NPC1RAB9AKMT2AGAATSHR | |
| SCHEMBL7989176 | 0.84 | NPC1 (0.55) | NPC1RAB9AKMT2AGAATSHR | |
| SCHEMBL7991736 | 0.83 | RAB9A (0.54) | NPC1RAB9AKMT2AGAATSHR | |
| SCHEMBL7977378 | 0.81 | RAB9A (0.52) | NPC1RAB9AKMT2AGAATSHR | |
| SCHEMBL7991845 | 0.81 | SMN1; SMN2 (0.44) | NPC1RAB9AKMT2AGAASMN1; SMN2 | |
| SCHEMBL7989590 | 0.81 | MAPT (0.53) | NPC1RAB9AKMT2AGAATSHR | |
| Hydrochloric Acid SCHEMBL7977698 | 0.80 | MAPT (0.53) | NPC1RAB9AKMT2AGAATSHR | |
| SCHEMBL7991835 | 0.80 | RAB9A (0.50) | NPC1RAB9AKMT2AGAATSHR | |
| SCHEMBL7978151 | 0.79 | RAB9A (0.51) | NPC1RAB9AKMT2AGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |