Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996058 | 0.89 | PDE4B (0.38) | PRMT6PDE4BPDE10AKDM4ENPC1 | |
| SCHEMBL7995980 | 0.88 | PRMT6 (0.38) | PRMT6PDE4BPDE10AKDM4ENPC1 | |
| SCHEMBL313117 | 0.87 | NPC1 (0.37) | PRMT6PDE4BPDE10AKDM4ENPC1 | |
| SCHEMBL7996037 | 0.81 | PDE10A (0.36) | PDE10AALDH1A1PDPK1DAPK3PRKD3 | |
| SCHEMBL312672 | 0.80 | CSF1R (0.37) | MAPT | |
| SCHEMBL8011560 | 0.78 | PDE4B (0.37) | PRMT6PDE4BPDE10AKDM4ENPC1 | |
| SCHEMBL313605 | 0.76 | PDE4B (0.37) | PRMT6PDE4BPDE10AKDM4ENPC1 | |
| SCHEMBL586097 | 0.76 | PRMT6 (0.37) | PRMT6PDE4BPDE10AKDM4ENPC1 | |
| SCHEMBL997578 | 0.76 | MEN1 (0.32) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL313603 | 0.75 | MAPT (0.37) | PRMT6PDE4BPDE10AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250174-B1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |