Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008953 | 0.88 | PDE10A (0.37) | PDE10AALDH1A1 | |
| SCHEMBL8007978 | 0.88 | G6PD (0.33) | PDE10A | |
| SCHEMBL313042 | 0.86 | PDE10A (0.36) | PDE10A | |
| SCHEMBL7995997 | 0.81 | PRMT6 (0.41) | PDE10APDPK1DAPK3PRKD3FLT1 | |
| SCHEMBL585811 | 0.76 | PDE10A (0.32) | PDE10A | |
| SCHEMBL2834386 | 0.76 | — | — | |
| SCHEMBL313186 | 0.74 | CYP19A1 (0.32) | PDE10A | |
| SCHEMBL14864639 | 0.73 | KDM4E (0.45) | PDE10AALDH1A1 | |
| SCHEMBL11949921 | 0.73 | PDE10A (0.36) | PDE10AALDH1A1 | |
| SCHEMBL3658240 | 0.71 | MAPT (0.42) | RAD52ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250174-B1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |