Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009318 | 0.90 | HPGD (0.45) | LMNANFKB1SMN1; SMN2SLC9A1KMT2A | |
| Hydrochloric Acid SCHEMBL8007241 | 0.89 | HPGD (0.45) | SMN1; SMN2SLC9A1KMT2ACYP1A2HTR2B | |
| Hydrochloric Acid SCHEMBL8007228 | 0.85 | KMT2A (0.43) | ALDH1A1POLBSMN1; SMN2SLC9A1KMT2A | |
| SCHEMBL7996045 | 0.85 | LMNA (0.45) | LMNAALDH1A1SLC22A1SLC22A2TSHR | |
| Hydrochloric Acid SCHEMBL7996052 | 0.84 | LMNA (0.46) | LMNAALDH1A1SLC22A1SLC22A2TSHR | |
| SCHEMBL7995581 | 0.84 | MCHR1 (0.46) | LMNAALDH1A1SLC22A1SLC22A2TSHR | |
| Hydrochloric Acid SCHEMBL8007340 | 0.80 | SMN1; SMN2 (0.42) | NFKB1SMN1; SMN2SLC9A1KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL8004416 | 0.80 | SMN1; SMN2 (0.43) | LMNAALDH1A1MAPK1POLBSMN1; SMN2 | |
| SCHEMBL8664616 | 0.78 | MAPK1 (0.47) | LMNAALDH1A1TSHRMAPK1POLB | |
| Hydrochloric Acid SCHEMBL8007354 | 0.75 | GAA (0.50) | LMNAALDH1A1TSHRMAPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017917-A | Guanidine derivatives | FUJISAWA PHARAMCEUTICAL CO., LTD. (JP) | 2000-01-25 | — | — | US | claimed |
| EP-0876338-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | claimed |
| WO-1997025310-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-17 | — | — | WO | claimed |