Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | GLB1 | P16278 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | EBP | Q15125 | 1/20 | 0.32 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12337636 | 0.81 | MEN1 (0.46) | SIGMAR1MEN1KMT2A | |
| SCHEMBL14156564 | 0.80 | CYP1A2 (0.35) | GLB1GNAI3GNAO1GNAI1S1PR1 | |
| SCHEMBL20758649 | 0.80 | CYP1A2 (0.37) | SIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL21567209 | 0.79 | KDM4E (0.32) | SIGMAR1 | |
| SCHEMBL21015481 | 0.79 | KDM4E (0.35) | SIGMAR1MEN1KMT2A | |
| SCHEMBL11571899 | 0.79 | — | — | |
| SCHEMBL24802087 | 0.76 | SIGMAR1 (0.35) | SIGMAR1MEN1KMT2A | |
| SCHEMBL5821937 | 0.76 | DRD2 (0.35) | SIGMAR1MEN1KMT2A | |
| SCHEMBL12439866 | 0.76 | SIGMAR1 (0.35) | SIGMAR1MEN1KMT2A | |
| SCHEMBL25873415 | 0.76 | SIGMAR1 (0.35) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117283-A2 | QUINOLIZIDINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |