SCHEMBL7996324

SCHEMBL7996324

Cc1cc(Cl)ncc1C=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
ALDH1A1 P00352 6/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
KDM4E B2RXH2 2/20 0.40
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
MPI P34949 1/20 0.40
KMT2A Q03164 1/20 0.40
GRIA1 P42261 1/20 0.37
GRIA2 P42262 1/20 0.37
GRIA3 P42263 1/20 0.37
GRIA4 P48058 1/20 0.37
TSHR P16473 1/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
ERN1 O75460 2/20 0.34
KCNQ3 O43525 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5118435 0.83 CYP1A2 (0.42) CYP3A4CYP2C19CYP1A2CYP2D6ALDH1A1
SCHEMBL29878553 0.83 CYP1A2 (0.42) CYP3A4CYP2C19CYP1A2CYP2D6ALDH1A1
SCHEMBL13521756 0.79 ALDH1A1 (0.35) CYP3A4CYP2C19ALDH1A1KDM4ECHRNB2
SCHEMBL31412448 0.79 ALDH1A1 (0.35) CYP3A4CYP2C19ALDH1A1KDM4ECHRNB2
SCHEMBL30424169 0.79 CHRNB2 (0.33) ALDH1A1CHRNB2CHRNA4KCNQ3KCNQ2
SCHEMBL29411195 0.78 TDP1 (0.45) CYP3A4CYP2C19CYP1A2CYP2D6ALDH1A1
SCHEMBL899188 0.78 TDP1 (0.45) CYP3A4CYP2C19CYP1A2CYP2D6ALDH1A1
SCHEMBL6631118 0.78 UHRF1 (0.46) CYP3A4CYP2C19CYP1A2CYP2D6ALDH1A1
SCHEMBL29954921 0.78 UHRF1 (0.46) CYP3A4CYP2C19CYP1A2CYP2D6ALDH1A1
SCHEMBL24052805 0.78 ALDH1A1 (0.34) CYP3A4ALDH1A1CHRNB2CHRNA4KCNQ3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 EP disclosed
EP-4630410-A1 POLQ INHIBITORS Astrazeneca AB (SE) 2025-10-15 EP disclosed
US-12414954-B2 POLQ inhibitors ASTRAZENECA AB (SE) 2025-09-16 US disclosed
US-20250195530-A1 POLQ INHIBITORS ASTRAZENECA AB (SE) 2025-06-19 US disclosed
US-20240366615-A1 POLQ INHIBITORS ASTRAZENECA UK LIMITED (GB) 2024-11-07 US disclosed
WO-2024218503-A1 SOLID FORMS OF AN ENZYME INHIBITOR AND SALTS THEREOF KALVISTA PHARMACEUTICALS LIMITED (GB) 2024-10-24 WO disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 WO disclosed
US-20240327390-A1 SUBSTITUTED NITROGEN CONTAINING COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2024-10-03 US disclosed
WO-2024121753-A1 POLQ INHIBITORS ASTRAZENECA AB (SE) 2024-06-13 WO disclosed
EP-3929194-B1 SUBSTITUTED NITROGEN CONTAINING COMPOUNDS BRISTOL MYERS SQUIBB CO (US) 2024-04-17 EP disclosed
US-6022967-A 1-NITRO-2-CARBOXYVINYL- OR 1-NITRO-2-(DIMETHYLAMINO)VINYL-SUBSTITUTED IMIDAZOLIDINES OR TETRAHYDROPYRIMIDINES NIHON BAYER AGROCHEM K.K. (JP) 2000-02-08 US disclosed
US-5750704-A INSECTICIDES NIHON BAYER AGROCHEM K.K. (JP) 1998-05-12 US disclosed
US-5580889-A Insecticidal nitromethyl or niteoimino-heteromethyl-heterocyclics NIHON BAYER AGROCHEM K.K. (JP) 1996-12-03 US disclosed
US-5461167-A 2-chloro-5-chloromethyl thiazole; insecticide NIHON BAYER AGROCHEM K.K. (JP) 1995-10-24 US disclosed
US-5298507-A Insecticides NIHON BAYER AGROCHEM K.K. (JP) 1994-03-29 US disclosed
US-5204360-A Insecticides NIHON BAYER AGROCHEM K.K. (JP) 1993-04-20 US disclosed
US-5001138-A Insecticides NIHON TOKUSHU NOYAKU SEIZO, K.K. (JP) 1991-03-19 US disclosed
US-4845106-A INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1989-07-04 US disclosed
US-4742060-A 2-(NITROIMINO)- OR 2-(NITROMETHYLENE)-IMIDAZOLIDINES AS INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) 1988-05-03 US disclosed
EP-0192060-A1 Heterocyclic compounds NIHON BAYER AGROCHEM K.K. (JP) 1986-08-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240327390-A1 SUBSTITUTED NITROGEN CONTAINING COMPOUNDS NR0B1, GRK1, GRIN1 CYP3A4 1597/4885CYP2C19 1582/4885CYP1A2 1414/4885
US-20240366615-A1 POLQ INHIBITORS POLQ, POLG, POLB CYP3A4 2422/4885CYP2C19 1292/4885CYP1A2 1577/4885
US-12414954-B2 POLQ inhibitors POLQ, POLG, POLB CYP3A4 2422/4885CYP2C19 1292/4885CYP1A2 1577/4885
US-20250195530-A1 POLQ INHIBITORS POLQ, POLG, POLB CYP3A4 2422/4885CYP2C19 1292/4885CYP1A2 1577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.