Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA4 | P22748 | 2/20 | 0.55 |
| ▸ | CA6 | P23280 | 2/20 | 0.55 |
| ▸ | CA5A | P35218 | 2/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.55 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.53 |
| ▸ | ABAT | P80404 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22005162 | 0.86 | ALDH1A1 (0.64) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL27624350 | 0.86 | ESR1 (0.56) | MAPTSMN1; SMN2LMNACA12CA1 | |
| SCHEMBL4048717 | 0.85 | ALDH1A1 (0.58) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL2232877 | 0.85 | ALDH1A1 (0.58) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL8589028 | 0.84 | RAB9A (0.61) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL2231514 | 0.83 | ALDH1A1 (0.63) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL2231178 | 0.83 | ALDH1A1 (0.66) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL2232493 | 0.83 | ALDH1A1 (0.63) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL2231854 | 0.83 | ALDH1A1 (0.61) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL2232274 | 0.83 | ALDH1A1 (0.61) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |
| EP-0991632-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | Astra Aktiebolag (SE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057941-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |