Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.47 |
| ▸ | YAP1 | P46937 | 1/20 | 0.47 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.47 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698739 | 0.94 | KDM4E (0.56) | KDM4EALDH1A1TEAD1YAP1TEAD4 | |
| SCHEMBL8529367 | 0.89 | CA2 (0.55) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL11540114 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1TEAD1YAP1TEAD4 | |
| SCHEMBL8637757 | 0.82 | CA2 (0.61) | KDM4EALDH1A1TEAD1YAP1TEAD4 | |
| SCHEMBL9808062 | 0.79 | TEAD1 (0.53) | KDM4EALDH1A1TEAD1YAP1TEAD4 | |
| SCHEMBL10916274 | 0.79 | KDM4E (0.59) | KDM4EALDH1A1TEAD1YAP1TEAD4 | |
| SCHEMBL8955502 | 0.78 | HDAC3 (0.58) | KDM4EALDH1A1TEAD1YAP1TEAD4 | |
| SCHEMBL26116458 | 0.78 | HDAC3 (0.58) | KDM4EALDH1A1TEAD1YAP1TEAD4 | |
| SCHEMBL7078809 | 0.77 | HPGD (0.53) | KDM4EALDH1A1TEAD1YAP1TEAD4 | |
| SCHEMBL7018220 | 0.76 | CYP2A6 (0.43) | KDM4EALDH1A1TEAD1YAP1TEAD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288261-B1 | DRUGS FOR INHIBITION OF ENZYMES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | disclosed |