Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31522154 | 1.00 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1GAATDP1MAPT | |
| SCHEMBL10360452 | 0.89 | L3MBTL1 (0.59) | ALDH1A1L3MBTL1TDP1MAPTMEN1 | |
| SCHEMBL31522169 | 0.87 | L3MBTL1 (0.58) | ALDH1A1L3MBTL1TDP1MAPTMEN1 | |
| SCHEMBL30668812 | 0.84 | L3MBTL1 (0.64) | ALDH1A1L3MBTL1TDP1MAPTMEN1 | |
| SCHEMBL1339905 | 0.84 | L3MBTL1 (0.64) | ALDH1A1L3MBTL1TDP1MAPTMEN1 | |
| SCHEMBL13400264 | 0.84 | MEN1 (0.67) | ALDH1A1GAAMAPTMEN1KMT2A | |
| SCHEMBL9688249 | 0.83 | MAPT (0.58) | ALDH1A1L3MBTL1GAATDP1MAPT | |
| SCHEMBL10417311 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL8695351 | 0.82 | L3MBTL1 (0.60) | ALDH1A1L3MBTL1TDP1MAPTMEN1 | |
| SCHEMBL31522167 | 0.82 | L3MBTL1 (0.60) | ALDH1A1L3MBTL1TDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |