Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11972313 | 0.86 | CA12 (0.53) | RAB9AMAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2180427 | 0.85 | SMN1; SMN2 (0.58) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL2294258 | 0.85 | LMNA (0.54) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL2177301 | 0.85 | MAPT (0.52) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL892695 | 0.85 | SMN1; SMN2 (0.58) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL11972337 | 0.84 | RAB9A (0.57) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 | |
| SCHEMBL11509779 | 0.82 | PPARG (0.48) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2117865 | 0.82 | KDM4E (0.52) | MAPTKDM4EHSP90AA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2296719 | 0.81 | RAB9A (0.54) | RAB9AMAPTSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL21317626 | 0.81 | POLB (0.45) | RAB9AMAPTNPC1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-B1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | TAIJI BIOMEDICAL INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-2082740-A2 | Use of imidazole derivatives as MDR modulators | Taiji Biomedical, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2000033836-A9 | 5-MEMBERED HETEROCYCLES FOR THE TREATMENT OF HUMAN DISEASES INVOLVING MODULATORS OF SELECTINS | ONTOGEN CORP (US) | 2001-10-04 | — | — | WO | disclosed |
| WO-2000033836-A1 | 5-MEMBERED HETEROCYCLES FOR THE TREATMENT OF HUMAN DISEASES INVOLVING MODULATORS OF SELECTINS | ONTOGEN CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |