Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1568740 | 0.86 | CYP19A1 (0.47) | LMNARAB9ANOS1METAP2ALDH1A1 | |
| SCHEMBL1554684 | 0.79 | DAO (0.44) | ITKAHRCYP2A6 | |
| SCHEMBL7019205 | 0.78 | AOC3 (0.45) | LMNARAB9AALDH1A1ESR1CYP2A6 | |
| SCHEMBL22529412 | 0.70 | LMNA (0.41) | LMNARAB9AITKNOS1METAP2 | |
| SCHEMBL475358 | 0.70 | LMNA (0.52) | LMNARAB9AITKNOS1METAP2 | |
| SCHEMBL30697897 | 0.70 | LMNA (0.52) | LMNARAB9AITKNOS1METAP2 | |
| SCHEMBL19228606 | 0.69 | LMNA (0.40) | LMNARAB9AITKNOS1METAP2 | |
| SCHEMBL7008123 | 0.69 | ITK (0.43) | ITKNOS1ALDH1A1AHRHRH4 | |
| SCHEMBL3364704 | 0.69 | AHR (0.50) | ITKNOS1METAP2DYRK1AALDH1A1 | |
| SCHEMBL17433431 | 0.69 | ITK (0.51) | RAB9AITKNOS1METAP2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001032660-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR ANTAGONIST ACTIVITY | NPS ALLELIX CORP. (US) | 2001-05-10 | — | — | WO | disclosed |