SCHEMBL7019205

SCHEMBL7019205

CC(C)[Si](c1cc2ccccc2[nH]1)(C(C)C)C(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 2/20 0.45
BRD4 O60885 1/20 0.44
KDM4E B2RXH2 4/20 0.44
LMNA P02545 2/20 0.44
TP53 P04637 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.41
FLT3 P36888 1/20 0.41
CYP2A6 P11509 1/20 0.41
AURKA O14965 1/20 0.41
AURKB Q96GD4 1/20 0.41
MAPT P10636 2/20 0.41
HSD17B10 Q99714 2/20 0.41
ALDH1A1 P00352 1/20 0.41
ALOX5 P09917 1/20 0.41
DAO P14920 2/20 0.40
HPGD P15428 1/20 0.40
SRD5A2 P31213 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3608256 0.79 AOC3 (0.48) AOC3BRD4KDM4ENPC1RAB9A
SCHEMBL30559751 0.79 AOC3 (0.48) AOC3BRD4KDM4ENPC1RAB9A
SCHEMBL30559750 0.79 AOC3 (0.48) AOC3BRD4KDM4ENPC1RAB9A
SCHEMBL1554684 0.78 DAO (0.44) KDM4EFLT3CYP2A6DAODDO
SCHEMBL1568740 0.78 CYP19A1 (0.47) LMNARAB9AFLT3CYP2A6ALDH1A1
SCHEMBL7997552 0.78 LMNA (0.43) LMNARAB9ACYP2A6ALDH1A1ESR1
SCHEMBL15791226 0.76 AOC3 (0.45) AOC3BRD4KDM4ENPC1RAB9A
SCHEMBL19557306 0.74 ALDH1A1 (0.47) AOC3BRD4KDM4ENPC1RAB9A
SCHEMBL9211604 0.74 PRMT5 (0.41) BRD4LMNAHPGD
SCHEMBL7325948 0.74 CA1 (0.41) KDM4EALDH1A1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106279236-B Method for synthesizing 2-triisopropyl silicon-based acetylene indole compound 南京理工大学 2020-04-10 CN disclosed
CN-106279236-A A kind of method of synthesis 2 triisopropylsilyl acetylene Benzazole compounds 南京理工大学 2017-01-04 CN disclosed
EP-0574174-B1 Angiotensin II antagonists LILLY CO ELI (US) 2003-08-13 EP disclosed
WO-2000000490-A2 5-HT1F AGONISTS ELI LILLY AND COMPANY (US) 2000-01-06 WO disclosed
US-5693633-A Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1997-12-02 US disclosed
US-5612360-A AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS ELI LILLY AND COMPANY (US) 1997-03-18 US disclosed
US-5569768-A USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY ELI LILLY AND COMPANY (US) 1996-10-29 US disclosed
US-5556981-A Angiotensin II antagonist intermediates ELI LILLY AND COMPANY (US) 1996-09-17 US disclosed
EP-0574174-A2 Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1993-12-15 EP disclosed