Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.49 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CTSA | P10619 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | SIK1 | P57059 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19153327 | 0.78 | ALDH1A1 (0.53) | ERN1PDGFRBPDGFRAALDH1A1TRIM24 | |
| SCHEMBL8782875 | 0.78 | HDAC8 (0.59) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL8503242 | 0.78 | MAOB (0.52) | ERN1PDGFRBPDGFRAMAOBMAOA | |
| SCHEMBL4740926 | 0.77 | GPBAR1 (0.59) | ERN1PDGFRBPDGFRAMAOBMAOA | |
| SCHEMBL16697416 | 0.76 | ALDH1A1 (0.54) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL14919460 | 0.76 | ERN1 (0.51) | ERN1PDGFRBPDGFRAMAOBPELI1 | |
| SCHEMBL18003620 | 0.76 | PDGFRB (0.49) | ERN1PDGFRBPDGFRAMAOBMAOA | |
| SCHEMBL6535988 | 0.75 | ERN1 (0.61) | ERN1ALDH1A1TRIM24TRIM33PELI1 | |
| SCHEMBL18284498 | 0.75 | ALDH1A1 (0.53) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL4392162 | 0.75 | ALDH1A1 (0.53) | ERN1MAOBALDH1A1TRIM24TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000008202-A2 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN, INC. (US) | 2000-02-17 | — | — | WO | disclosed |