Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19153107 | 0.90 | MDM2 (0.49) | ALDH1A1TRIM24TYRTRIM33MDM2 | |
| SCHEMBL18284498 | 0.84 | ALDH1A1 (0.53) | ALDH1A1TRIM24TYRTRIM33MDM2 | |
| SCHEMBL8782875 | 0.83 | HDAC8 (0.59) | ALDH1A1TRIM24TYRTRIM33ERN1 | |
| SCHEMBL19153822 | 0.81 | ERN1 (0.43) | ALDH1A1MDM2ERN1NFE2L2MEN1 | |
| SCHEMBL19153327 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TRIM24TYRTRIM33ERN1 | |
| SCHEMBL10899584 | 0.80 | ALDH1A1 (0.49) | ALDH1A1TRIM24TYRTRIM33MDM2 | |
| SCHEMBL8514117 | 0.80 | AKR1A1 (0.44) | ALDH1A1MAPK14HDAC8MAOB | |
| SCHEMBL19154093 | 0.80 | ERN1 (0.50) | ALDH1A1TRIM24TYRTRIM33MDM2 | |
| SCHEMBL16055890 | 0.80 | ERN1 (0.41) | ALDH1A1TRIM24TYRTRIM33MDM2 | |
| SCHEMBL28854283 | 0.79 | ALDH1A1 (0.60) | ALDH1A1TRIM24TYRTRIM33ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626046-B1 | Photochromic oxazine compounds and methods for their manufacture | ESSILOR INT (FR) | 2014-11-19 | — | — | EP | disclosed |
| EP-1458695-B1 | Method for the manufacture of photochromic oxazine compounds and compounds obtainable therefrom | ESSILOR INT (FR) | 2012-10-03 | — | — | EP | disclosed |
| EP-1446390-B1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INT (FR) | 2009-12-02 | — | — | EP | disclosed |
| EP-1626046-A1 | Photochromic oxazine compounds and methods for their manufacture | Johson & Johnson Vision Care Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1446390-A2 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2004-08-18 | — | — | EP | disclosed |
| US-6720420-B2 | AROMATIC, HETEROAROMATIC, OR ALIPHATIC SUBSTITUENTS AT THE 2 POSITION OF THE OXAZINE MOIETY; REACTING 3,3-DISUBSTITUTED ACRYLIC ACID, AZIDE SOURCE, QUINONE WITH CATALYTIC TRIPHENYLARSENIC OXIDE AND DBU; QUICKLY FADING GRAY COLOR | JOHNSON & JOHNSON VISION CARE, INC. | 2004-04-13 | — | — | US | disclosed |
| US-6686466-B2 | HEATING AN ISOCYANATE DERIVATIVE WITH A SYMMETRIC QUINONE IN PRESENCE OF TRIPHENYLARSEN OXIDE CATALYST TO FORM 2,2-DIPHENYL-PHENANTHRO (9,10)-2H-(1,4)-OXAZINE DERIVATIVES | JOHNSON & JOHNSON VISION CARE, INC. | 2004-02-03 | — | — | US | disclosed |
| US-20030149032-A1 | Photochromic oxazine compounds and methods for their manufacture | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2003-08-07 | — | — | US | disclosed |
| US-20030125552-A1 | Photochromic oxazine compounds and methods for their manufacture | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2003-07-03 | — | — | US | disclosed |
| WO-2003042195-A2 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2003-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149032-A1 | Photochromic oxazine compounds and methods for their manufacture | PPOX, TYR, DHPS | ALDH1A1 103/4885TRIM24 3357/4885TYR 2/4885 |
| US-20030125552-A1 | Photochromic oxazine compounds and methods for their manufacture | PPOX, DHPS, ALDH1A2 | ALDH1A1 120/4885TRIM24 3863/4885TYR 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.