Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1419874 | 0.84 | PDE10A (0.56) | PDE10ACYSLTR2CYSLTR1 | |
| SCHEMBL8003087 | 0.75 | CYSLTR1 (0.35) | PDE10ACYSLTR2CYSLTR1ALOX5FFAR1 | |
| SCHEMBL3328917 | 0.74 | PDE10A (0.56) | PDE10ACYSLTR2CYSLTR1ALOX5 | |
| SCHEMBL1420246 | 0.71 | PDE10A (0.56) | PDE10ACYSLTR2CYSLTR1 | |
| SCHEMBL30123334 | 0.67 | MAPK8 (0.57) | PDE10A | |
| SCHEMBL3269253 | 0.67 | MAPK8 (0.57) | PDE10A | |
| SCHEMBL1419880 | 0.67 | GPBAR1 (0.52) | PDE10ACYSLTR2CYSLTR1ALOX5FFAR1 | |
| SCHEMBL12169148 | 0.67 | PDE10A (0.52) | PDE10ACYSLTR2CYSLTR1ALOX5 | |
| SCHEMBL3329402 | 0.66 | PDE10A (0.53) | PDE10ACYSLTR2CYSLTR1 | |
| SCHEMBL8007284 | 0.66 | FFAR1 (0.38) | PDE10ACYP1A2CYSLTR2CYSLTR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158393-A1 | 1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |