Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420100 | 0.86 | CYSLTR1 (0.46) | CYSLTR1CYSLTR2FFAR1AKR1B1PDE10A | |
| SCHEMBL7998599 | 0.75 | PDE10A (0.42) | CYSLTR1CYSLTR2ALOX5FFAR1AKR1B1 | |
| SCHEMBL1419811 | 0.74 | CYSLTR2 (0.46) | CYSLTR1CYSLTR2FFAR1AKR1B1PDE10A | |
| SCHEMBL6995017 | 0.74 | PTGS2 (0.32) | — | |
| SCHEMBL1420116 | 0.67 | PDE10A (0.47) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL12169148 | 0.65 | PDE10A (0.52) | CYSLTR1CYSLTR2ALOX5PDE10AALOX5AP | |
| SCHEMBL1419880 | 0.65 | GPBAR1 (0.52) | CYSLTR1CYSLTR2ALOX5FFAR1AKR1B1 | |
| SCHEMBL3950944 | 0.65 | KCNH2 (0.61) | CYSLTR1CYSLTR2FFAR1AKR1B1PDE10A | |
| SCHEMBL1557935 | 0.64 | PTGS1 (0.53) | FFAR1AKR1B1PDE10A | |
| SCHEMBL8007284 | 0.62 | FFAR1 (0.38) | CYSLTR1CYSLTR2ALOX5FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158393-A1 | 1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |