SCHEMBL7998719

SCHEMBL7998719

CC(C)[C@](O)(CCc1ccc(O)cc1)CC(=O)O

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC13A5 Q86YT5 9/20 0.46
CA2 P00918 1/20 0.42
CAMK2A Q9UQM7 1/20 0.42
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
KDM4E B2RXH2 1/20 0.39
F13A1 P00488 1/20 0.39
ALDH1A1 P00352 2/20 0.39
PKM P14618 1/20 0.39
CYP3A4 P08684 1/20 0.38
BLM P54132 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7998721 1.00 SLC13A5 (0.46) SLC13A5CA2CAMK2AESR1ESR2
SCHEMBL6302904 0.87 SLC13A5 (0.49) SLC13A5KDM4EALDH1A1
SCHEMBL6695081 0.87 SLC13A5 (0.49) SLC13A5KDM4EALDH1A1
SCHEMBL6692391 0.87 SLC13A5 (0.49) SLC13A5KDM4EALDH1A1
SCHEMBL6297597 0.86 SLC13A5 (0.44) SLC13A5ALDH1A1CYP3A4
SCHEMBL8008239 0.86 SLC13A5 (0.44) SLC13A5
SCHEMBL6692548 0.86 SLC13A5 (0.44) SLC13A5ALDH1A1CYP3A4
SCHEMBL6691221 0.86 SLC13A5 (0.44) SLC13A5ALDH1A1CYP3A4
SCHEMBL6297833 0.84 SLC13A5 (0.49) SLC13A5KDM4E
SCHEMBL7998501 0.84 KDM4E (0.40) ESR1ESR2KDM4EF13A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP claimed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO claimed
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US disclosed
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP disclosed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US disclosed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed