SCHEMBL7998501

SCHEMBL7998501

COC(=O)C[C@@](O)(CCc1ccc(O)cc1)C(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.40
F13A1 P00488 1/20 0.40
CYP4F2 P78329 1/20 0.40
CYP4A11 Q02928 1/20 0.40
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
ABCG2 Q9UNQ0 1/20 0.37
CALM1 P0DP23 1/20 0.37
TMEM97 Q5BJF2 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
MET P08581 1/20 0.36
ESRRB O95718 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
ESRRG P62508 1/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MDM4 O15151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7998506 1.00 KDM4E (0.40) KDM4EF13A1CYP4F2CYP4A11ESR1
SCHEMBL7998719 0.84 SLC13A5 (0.46) KDM4EF13A1ESR1ESR2
SCHEMBL7998721 0.84 SLC13A5 (0.46) KDM4EF13A1ESR1ESR2
SCHEMBL8014867 0.82 FFAR1 (0.50) SIGMAR1NPC1RAB9ASMN1; SMN2
SCHEMBL6296483 0.79 FPR2 (0.38) KDM4ECYP4F2CYP4A11MEN1KMT2A
SCHEMBL6823355 0.78 NAAA (0.45) KMT2AMAPTSMN1; SMN2
SCHEMBL6303501 0.76 CYP19A1 (0.38) CYP4F2CYP4A11NPC1MAPTRAB9A
SCHEMBL6298205 0.76 HTT (0.41) MAPT
SCHEMBL6303423 0.74 CA12 (0.41) NPC1MAPTRAB9A
SCHEMBL6298317 0.74 ALDH1A1 (0.37) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP claimed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO claimed
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US disclosed
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP disclosed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US disclosed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed