Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.78 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | RAD52 | P43351 | 1/20 | 0.61 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821540 | 0.93 | HRH3 (0.86) | HRH3ACHERAD52 | |
| SCHEMBL2823878 | 0.91 | HRH3 (0.84) | HRH3ACHERAD52 | |
| SCHEMBL2820804 | 0.90 | HRH3 (0.82) | HRH3ACHERAD52 | |
| SCHEMBL12061359 | 0.88 | HRH3 (1.00) | HRH3ACHERAD52 | |
| SCHEMBL2823988 | 0.88 | HRH3 (1.00) | HRH3ACHERAD52 | |
| SCHEMBL4662212 | 0.88 | HRH3 (0.78) | HRH3ACHERAD52 | |
| SCHEMBL19043080 | 0.86 | HRH3 (0.77) | HRH3ACHERAD52LTA4H | |
| SCHEMBL12050749 | 0.85 | HRH3 (1.00) | HRH3ACHERAD52 | |
| SCHEMBL8107620 | 0.85 | HRH3 (0.75) | HRH3LTA4H | |
| SCHEMBL7999188 | 0.85 | HRH3 (0.75) | HRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2009117150-A2 | METHOD OF TREATING LUPUS WITH CERAMIDE DERIVATIVES | GENZYME CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |