Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 10/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.82 |
| ▸ | PGR | P06401 | 5/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.82 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.82 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.82 |
| ▸ | TNF | P01375 | 1/20 | 0.82 |
| ▸ | IL6 | P05231 | 1/20 | 0.82 |
| ▸ | AR | P10275 | 1/20 | 0.82 |
| ▸ | GLUL | P15104 | 1/20 | 0.82 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.82 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL2234173 | 0.97 | NR3C1 (0.88) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL122047 | 0.97 | NR3C1 (0.88) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL16094487 | 0.94 | NR3C1 (0.93) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL7514 | 0.94 | NR3C1 (0.93) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL5504548 | 0.94 | NR3C1 (0.93) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL1930093 | 0.93 | NR3C1 (0.88) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL2810130 | 0.93 | NR3C1 (0.91) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL1270167 | 0.93 | NR3C1 (0.91) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL2233875 | 0.93 | NR3C1 (0.90) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL23564 | 0.93 | NR3C1 (0.90) | NR3C1HIF1AHSD17B10PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831912-A4 | IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS | OCULEX PHARM INC (US) | 2000-08-30 | — | — | EP | disclosed |
| EP-0831912-A1 | IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS | OCULEX PHARMACEUTICALS, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996038174-A1 | IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS | OCULEX PHARMACEUTICALS, INC. (US) | 1996-12-05 | — | — | WO | disclosed |