E324

E324

SCHEMBL7999894

CCOc1ccc2c(c1)C(C)=CC(C)(C)N2.CCOc1ccc2c(c1)C(C)=CC(C)(C)N2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 12/20 1.00
KDM4E B2RXH2 8/20 1.00
HPGD P15428 8/20 1.00
HSD17B10 Q99714 7/20 1.00
LMNA P02545 7/20 1.00
MEN1 O00255 6/20 1.00
KMT2A Q03164 6/20 1.00
TDP1 Q9NUW8 5/20 1.00
CYP3A4 P08684 3/20 1.00
ALOX12 P18054 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2D6 P10635 2/20 1.00
CYP2C9 P11712 2/20 1.00
CYP2C19 P33261 2/20 1.00
ALOX15 P16050 1/20 1.00
HIF1A Q16665 1/20 1.00
GAA P10253 2/20 0.61
MAPT P10636 11/20 0.59
L3MBTL1 Q9Y468 4/20 0.59
MAPK1 P28482 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
E324 SCHEMBL21601 1.00 ALDH1A1 (1.00) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL29357397 1.00 ALDH1A1 (1.00) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL27554157 0.98 ALDH1A1 (0.97) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL27314758 0.98 ALDH1A1 (0.97) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL27371041 0.98 ALDH1A1 (0.97) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL27419374 0.98 ALDH1A1 (0.97) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL11191719 0.98 ALDH1A1 (0.97) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL8118295 0.98 ALDH1A1 (0.97) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL27325190 0.98 ALDH1A1 (0.97) ALDH1A1KDM4EHPGDHSD17B10LMNA
E324 SCHEMBL27951085 0.98 ALDH1A1 (0.97) ALDH1A1KDM4EHPGDHSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6017564-A Treatment of stressed animals with dihydroxyquinoline compounds SOLUTIA INC. (US) 2000-01-25 US disclosed
EP-0185142-A2 Fat mixtures as animal feeding-stuffs additive and feeding-stuffs produced thereof Karwendel-Werke Franz X. Huber (DE) 1986-06-25 EP disclosed
US-4592915-A Using a 1,2-dihydroquinoline compound GOYETTE LEWIS E 1986-06-03 US disclosed
US-4259218-A TIRES HAVING SUPERIOR BLOWOUT RESISTANCE AND LOW HEAT BUILDUP PHILLIPS PETROLEUM COMPANY (US) 1981-03-31 US disclosed