Sugi Predict

Sugi Predict / Compounds / SCHEMBL8000408

SCHEMBL8000408

SCHEMBL8000408

O=S(=O)(OCCc1ccc(OS(=O)(=O)C(F)(F)F)cc1)C(F)(F)F

nearest known ligand 0.67

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 9/20 0.67
▸ CA1 P00915 8/20 0.67
▸ CA9 Q16790 3/20 0.43
▸ PTPRZ1 P23471 1/20 0.39
▸ HTR1A P08908 2/20 0.39
▸ HTR1D P28221 2/20 0.39
▸ HTR1B P28222 2/20 0.39
▸ CXCR2 P25025 2/20 0.38
▸ STS P08842 2/20 0.38
▸ CXCR1 P25024 1/20 0.38
▸ CA12 O43570 1/20 0.37
▸ CA7 P43166 1/20 0.37
▸ DRD2 P14416 1/20 0.36
▸ DRD1 P21728 1/20 0.36
▸ DRD4 P21917 1/20 0.36
▸ DRD5 P21918 1/20 0.36
▸ DRD3 P35462 1/20 0.36
▸ PPARG P37231 1/20 0.36
▸ PPARA Q07869 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23291910 0.84 CA2 (0.69) CA2CA1CA9CA12
SCHEMBL17847695 0.84 CA2 (0.46) CA2CA1CA9PTPRZ1HTR1A
SCHEMBL6586107 0.84 CA2 (0.68) CA2CA1CA9CA12CA7
SCHEMBL14360354 0.83 CA2 (0.67) CA2CA1CA9PPARA
SCHEMBL27975808 0.83 CA2 (0.71) CA2CA1CA9CA12CA7
SCHEMBL5496662 0.83 CA2 (0.67) CA2CA1CA9CA12PPARG
SCHEMBL17966286 0.83 CA2 (0.67) CA2CA1CA9PPARA
SCHEMBL6941010 0.82 PPARA (0.51) CA2CA1CA9PTPRZ1HTR1A
SCHEMBL26619697 0.81 HTR1A (0.52) CA2CA1CA9HTR1AHTR1D
SCHEMBL7771915 0.81 CA2 (0.44) CA2CA1CA9PTPRZ1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289781-A1 TRIFLUOROMETHANESULFONYLATING AGENT COMPOSITION AND METHOD FOR PRODUCING TRIFLUOROMETHANESULFONYLOXY COMPOUND OR TRIFLUOROMETHANESULFONYL COMPOUND CENTRAL GLASS COMPANY, LIMITED (JP) 2025-09-18 — — US disclosed
WO-2023214552-A1 TRIFLUOROMETHANE SULFONYLATION AGENT COMPOSITION AND METHOD FOR PRODUCING TRIFLUOROMETHANESULFONYLOXY COMPOUND OR TRIFLUOROMETHANE SULFONYL COMPOUND セントラル硝子株式会社 2023-11-09 — — WO disclosed
US-6288096-B1 ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS ASTRAZENECA AB (SE) 2001-09-11 — — US disclosed
EP-0991632-A1 NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES Astra Aktiebolag (SE) 2000-04-12 — — EP disclosed
WO-1998057941-A1 NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES ASTRA AKTIEBOLAG (SE) 1998-12-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250289781-A1 TRIFLUOROMETHANESULFONYLATING AGENT COMPOSITION AND METHOD FOR PRODUCING TRIFLUOROMETHANESULFONYLOXY COMPOUND OR TRIFLUOROMETHANESULFONYL COMPOUND AFF1, BRAF, AFF2 CA2 2177/4885CA1 542/4885CA9 572/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.