Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 4/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011492 | 0.88 | HRH1 (0.51) | DRD4HRH1HRH4HRH2HRH3 | |
| Oxalic Acid SCHEMBL8010108 | 0.83 | HRH1 (0.47) | DRD4HRH1HRH4HRH2HRH3 | |
| SCHEMBL8015866 | 0.78 | HTR1A (0.47) | HRH1HRH4DRD2HTR1AABCC1 | |
| SCHEMBL8009072 | 0.76 | DRD4 (0.73) | DRD4HRH1HRH4HRH2HRH3 | |
| SCHEMBL8012631 | 0.75 | HRH1 (0.49) | DRD4HRH1HRH4HRH2HRH3 | |
| Oxalic Acid SCHEMBL8011723 | 0.72 | DRD4 (0.67) | DRD4HRH1HRH4HRH2HRH3 | |
| SCHEMBL8008902 | 0.71 | HRH1 (0.47) | DRD4HRH1HRH4HRH2HRH3 | |
| Oxalic Acid SCHEMBL8011549 | 0.71 | HRH1 (0.46) | HRH1HRH4HRH2HRH3DRD2 | |
| SCHEMBL8010052 | 0.70 | DRD4 (0.64) | DRD4DRD2HTR1AABCC1SIGMAR1 | |
| SCHEMBL8009156 | 0.70 | DRD4 (0.67) | DRD4HRH1HRH4HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080745-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| WO-1995007893-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |