Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011492 | 0.95 | HRH1 (0.51) | HRH1HRH4HRH2HRH3DRD4 | |
| SCHEMBL8015866 | 0.85 | HTR1A (0.47) | HRH1HRH4DRD2HTR1AMEN1 | |
| Oxalic Acid SCHEMBL8011549 | 0.84 | HRH1 (0.46) | HRH1HRH4HRH2HRH3DRD2 | |
| SCHEMBL8000858 | 0.83 | DRD4 (0.47) | HRH1HRH4HRH2HRH3DRD4 | |
| Oxalic Acid SCHEMBL8011723 | 0.80 | DRD4 (0.67) | HRH1HRH4HRH2HRH3DRD4 | |
| SCHEMBL8012631 | 0.78 | HRH1 (0.49) | HRH1HRH4HRH2HRH3DRD4 | |
| SCHEMBL8010100 | 0.75 | KDR (0.49) | DRD4DRD2SIGMAR1HTR2CHTR1A | |
| SCHEMBL8008914 | 0.74 | SMARCA2 (0.45) | HRH1HRH4HRH2HRH3 | |
| SCHEMBL8009072 | 0.74 | DRD4 (0.73) | HRH1HRH4HRH2HRH3DRD4 | |
| SCHEMBL8008902 | 0.72 | HRH1 (0.47) | HRH1HRH4HRH2HRH3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080745-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0724572-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1998-12-16 | — | — | EP | disclosed |
| EP-0724572-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995007893-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |