Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL3728867 | 0.93 | GABRR1 (0.48) | TP53GABRR1RNPEPALDH1A1TSHR | |
| Lactic Acid SCHEMBL22346344 | 0.91 | TP53 (0.61) | TP53GABRR1ALDH1A1TSHRLMNA | |
| Lactic Acid SCHEMBL27177897 | 0.91 | TP53 (0.61) | TP53GABRR1ALDH1A1TSHRLMNA | |
| Lactic Acid SCHEMBL1831319 | 0.91 | TP53 (0.61) | TP53GABRR1ALDH1A1TSHRLMNA | |
| Lactic Acid SCHEMBL215975 | 0.88 | TP53 (0.58) | TP53GABRR1RNPEPALDH1A1TSHR | |
| Lactic Acid SCHEMBL8334225 | 0.82 | TP53 (0.50) | TP53GABRR1RNPEPALDH1A1TSHR | |
| Lactic Acid SCHEMBL31326881 | 0.80 | TP53 (0.69) | TP53GABRR1RNPEPLMNASLC7A5 | |
| Ethylene Glycol SCHEMBL1171441 | 0.80 | RNPEP (0.48) | TP53GABRR1RNPEPALDH1A1ACE | |
| Ethylene Glycol SCHEMBL28854573 | 0.80 | RNPEP (0.48) | TP53GABRR1RNPEPALDH1A1ACE | |
| Ethylene Glycol SCHEMBL29686923 | 0.80 | RNPEP (0.48) | TP53GABRR1RNPEPALDH1A1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011609-A4 | COMPOSITIONS FOR COSMETIC APPLICATIONS | MEDLOGIC GLOBAL CORP (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-1011609-A1 | COMPOSITIONS FOR COSMETIC APPLICATIONS | MedLogic Global Corporation (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998050005-A1 | COMPOSITIONS FOR COSMETIC APPLICATIONS | MEDLOGIC GLOBAL CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |