Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8013772 | 0.98 | LMNA (0.39) | LMNASMN1; SMN2KDM4EHTTPOLB | |
| Bromide SCHEMBL7902851 | 0.81 | ALDH1A1 (0.47) | LMNASMN1; SMN2KDM4EHTTALDH1A1 | |
| SCHEMBL19626737 | 0.80 | RECQL (0.44) | LMNASMN1; SMN2KDM4EHTTPOLB | |
| SCHEMBL2381398 | 0.78 | ALDH1A1 (0.48) | LMNASMN1; SMN2KDM4EHTTALDH1A1 | |
| SCHEMBL27346476 | 0.77 | CYP19A1 (0.41) | LMNASMN1; SMN2KDM4EHTTPOLB | |
| SCHEMBL19625299 | 0.76 | LMNA (0.38) | LMNASMN1; SMN2KDM4EHTTPOLB | |
| Hydrochloric Acid SCHEMBL8013241 | 0.76 | CYP19A1 (0.40) | LMNASMN1; SMN2KDM4EHTTPOLB | |
| SCHEMBL2098453 | 0.73 | LMNA (0.41) | LMNASMN1; SMN2KDM4EHTTPOLB | |
| SCHEMBL2092103 | 0.70 | LMNA (0.40) | LMNASMN1; SMN2KDM4EHTTPOLB | |
| SCHEMBL2092106 | 0.70 | MAPT (0.37) | LMNASMN1; SMN2KDM4EHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057318-A | ANTAGONISTS OF PLATELET ACTIVATING FACTOR ACETHER | SANOFI (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5891894-A | 2-AMINO OXAZOLE DERIVATIVES; ANTAGONISTS OF PLATELET ACTIVATING FACTOR USEFUL IN TREATMENT OF ASTHMA, INFLAMMATION, CARDIOVASCULAR DISORDERS, RENAL DISEASES, OR AS CONTRACEPTIVES | SANOFI (FR) | 1999-04-06 | — | — | US | disclosed |
| US-5891893-A | 5-AMINO-1,2,4-OXA(OR THIA)DIAZOLES; ANTAGONISTS OF PLATELET ACTIVATING FACTOR USEFUL IN TREATMENT OF ASTHMA, ALLERGIES, INFLAMMATION, CARDIOVASCULAR DISEASES, RENAL DISEASES, OR AS CONTRACEPTIVES | SANOFI (FR) | 1999-04-06 | — | — | US | disclosed |
| US-5780468-A | ANTAGONIST OF PLATELET ACTIVATING FACTOR | SANOFI (FR) | 1998-07-14 | — | — | US | disclosed |
| US-5470855-A | Anticoagulants | SANOFI (FR) | 1995-11-28 | — | — | US | disclosed |
| CN-1028757-C | Heterocyclic derivatives, process for their preparation and their use as medicaments | SANOFI SA (FR) | 1995-06-07 | — | — | CN | disclosed |
| CN-1053064-A | PROCESS FOR PREPARING HETEROCYCLIC DERIVATIVES | SANOFI SA (FR) | 1991-07-17 | — | — | CN | disclosed |