Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.55 |
| ▸ | PTGES | O14684 | 7/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10962793 | 0.85 | PTGES (0.50) | PTGESPTGS2 | |
| SCHEMBL10509937 | 0.85 | PTGES (0.49) | PTGESPTGS2KDM4ECA12USP2 | |
| SCHEMBL30940077 | 0.84 | PTGES (0.56) | PTGESPTGS2KDM4ECA12USP2 | |
| SCHEMBL7342661 | 0.84 | PTGES (0.56) | PTGESPTGS2KDM4ECA12USP2 | |
| SCHEMBL11882115 | 0.83 | RHOA (0.54) | PTGESPTGS2KDM4ECA12USP2 | |
| SCHEMBL10564755 | 0.81 | PTGES (0.53) | PTGESPTGS2KDM4ECA12USP2 | |
| SCHEMBL4505248 | 0.79 | PTGES (0.57) | PTGESPTGS2KDM4ECA12USP2 | |
| Ethylparaben SCHEMBL16416596 | 0.78 | CA12 (0.56) | HSD11B1KDM4ECA12USP2CA1 | |
| SCHEMBL6720568 | 0.77 | PTGES (0.62) | PTGESPTGS2KDM4ECA12USP2 | |
| Saccharin SCHEMBL29283763 | 0.77 | CA12 (0.65) | HSD11B1KDM4ECA12USP2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001040208-A2 | PROCESS FOR SYNTHESIS OF 4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDES | AD 'ZDRAVLJE' (YU) | 2001-06-08 | — | — | WO | claimed |
| US-4116964-A | 2-[(N-2-pyridylcarbamoyl)methyl]saccharin | WARNER-LAMBERT COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4074048-A | Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides | WARNER-LAMBERT COMPANY (US) | 1978-02-14 | — | — | US | disclosed |