SCHEMBL8001973

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1496829	0.91	ROCK2 (0.43)	ROCK2KCNQ4KCNQ5ROCK1CYP3A4
	SCHEMBL1497071	0.91	ROCK2 (0.39)	ROCK2KCNQ4KCNQ5ROCK1HDAC1
	SCHEMBL1496834	0.91	ROCK2 (0.46)	ROCK2KCNQ4KCNQ5ROCK1CYP3A4
	SCHEMBL1497472	0.90	ROCK2 (0.39)	ROCK2ROCK1CYP3A4CYP2D6CYP2C9
	SCHEMBL1497449	0.90	ROCK2 (0.42)	ROCK2KCNQ4KCNQ5ROCK1CYP3A4
	SCHEMBL1496860	0.90	ROCK2 (0.38)	ROCK2KCNQ4KCNQ5ROCK1HDAC1
	SCHEMBL8004078	0.89	ROCK2 (0.42)	ROCK2ROCK1CYP3A4CYP2D6CYP2C9
	SCHEMBL1497457	0.88	PDCD1 (0.37)	ROCK2ROCK1HDAC1
	SCHEMBL1497069	0.87	PDCD1 (0.36)	ROCK2ROCK1HDAC1
	SCHEMBL1497118	0.87	NAMPT (0.45)	ROCK2ROCK1NPC1ALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.