Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 20/20 | 0.54 |
| ▸ | MMP2 | P08253 | 19/20 | 0.54 |
| ▸ | MMP1 | P03956 | 9/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8001943 | 0.92 | MMP9 (0.58) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL8000265 | 0.87 | MMP9 (0.55) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL7990305 | 0.84 | MMP9 (0.62) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL8000271 | 0.83 | MMP9 (0.58) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL7999199 | 0.83 | MMP9 (0.52) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL8000234 | 0.82 | MMP9 (0.55) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL8001762 | 0.81 | MMP9 (0.56) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL7990310 | 0.81 | MMP9 (0.53) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL7990017 | 0.80 | MMP9 (0.48) | MMP9MMP2MMP1MMP3MMP7 | |
| SCHEMBL4638907 | 0.72 | MMP1 (0.59) | MMP9MMP2MMP1MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | claimed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |