Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | PPP3CB | P16298 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313037 | 0.92 | UCHL1 (0.39) | UCHL1CTSBPPP3CBPDE4BPDE11A | |
| SCHEMBL3808212 | 0.92 | UCHL1 (0.39) | UCHL1CTSBPPP3CBPDE4BPDE11A | |
| SCHEMBL2213932 | 0.89 | UCHL1 (0.38) | UCHL1ABCC1ABCC2ABCG2CTSB | |
| SCHEMBL313204 | 0.89 | UCHL1 (0.38) | UCHL1ABCC1ABCC2ABCG2CTSB | |
| SCHEMBL1101736 | 0.89 | UCHL1 (0.38) | UCHL1ABCC1ABCC2ABCG2CTSB | |
| SCHEMBL8002276 | 0.88 | PDE4B (0.33) | UCHL1ABCC1ABCC2ABCG2CTSB | |
| SCHEMBL312718 | 0.86 | UCHL1 (0.37) | UCHL1CTSBPPP3CBPDE4BPDE11A | |
| SCHEMBL312719 | 0.86 | UCHL1 (0.37) | UCHL1CTSBPPP3CBPDE4BPDE11A | |
| SCHEMBL8002444 | 0.85 | UCHL1 (0.36) | UCHL1ABCC1ABCC2ABCG2CTSB | |
| SCHEMBL15216085 | 0.85 | UCHL1 (0.36) | UCHL1ABCC1ABCC2ABCG2CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250174-B1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |