Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.32 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | PPP3CB | P16298 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8006736 | 0.93 | CTSS (0.33) | PDE4BPDE11APDE10ACTSBPPP3CB | |
| SCHEMBL8002279 | 0.88 | UCHL1 (0.38) | PDE4BPDE11APDE10AABCC1ABCC2 | |
| SCHEMBL10247425 | 0.82 | PIK3CD (0.35) | UCHL1 | |
| SCHEMBL8002444 | 0.81 | UCHL1 (0.36) | ABCC1ABCC2ABCG2CTSBPPP3CB | |
| SCHEMBL15216085 | 0.81 | UCHL1 (0.36) | ABCC1ABCC2ABCG2CTSBPPP3CB | |
| SCHEMBL3808212 | 0.80 | UCHL1 (0.39) | PDE4BPDE11APDE10ACTSBPPP3CB | |
| SCHEMBL313037 | 0.80 | UCHL1 (0.39) | PDE4BPDE11APDE10ACTSBPPP3CB | |
| SCHEMBL312718 | 0.80 | UCHL1 (0.37) | PDE4BPDE11APDE10ACTSBPPP3CB | |
| SCHEMBL312719 | 0.80 | UCHL1 (0.37) | PDE4BPDE11APDE10ACTSBPPP3CB | |
| SCHEMBL10247252 | 0.77 | PIK3CD (0.35) | UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |