Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368227 | 0.85 | GRM5 (0.48) | HRH3GRM5KCNH2 | |
| SCHEMBL8001449 | 0.83 | GRM5 (0.48) | HRH3GRM5KCNH2 | |
| SCHEMBL8227864 | 0.83 | HRH3 (0.67) | HRH3GRM5KCNH2 | |
| SCHEMBL22860674 | 0.83 | KDM4E (0.48) | HRH3GRM5KCNH2 | |
| SCHEMBL12559564 | 0.82 | GRM5 (0.50) | HRH3GRM5 | |
| SCHEMBL17320372 | 0.82 | GRM5 (0.45) | HRH3GRM5AOC3KCNH2 | |
| SCHEMBL19565431 | 0.80 | HRH3 (0.44) | HRH3GRM5 | |
| SCHEMBL18055594 | 0.79 | HRH3 (0.42) | HRH3GRM5AOC3 | |
| SCHEMBL17320374 | 0.79 | GRM5 (0.43) | HRH3GRM5AOC3KCNH2 | |
| SCHEMBL12559553 | 0.78 | PARP10 (0.44) | HRH3GRM5AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299824-B1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME (US) | 2013-06-19 | — | — | EP | disclosed |
| US-20110144056-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME CORP. | 2011-06-16 | — | — | US | disclosed |
| WO-2009151991-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144056-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | FAAH, FAAH2, HRH2 | HRH3 24/4885GRM5 496/4885AOC3 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.