Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | PIR | O00625 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1437491 | 0.86 | AKR1B1 (0.34) | ACLYAKR1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8001344 | 0.77 | BRAF (0.34) | METAP2CYP3A4CYP2C9CYP2C19BRAF | |
| SCHEMBL8000164 | 0.76 | METAP2 (0.34) | METAP2CYP3A4CYP2C9CYP2C19BRAF | |
| SCHEMBL1437450 | 0.75 | KMT2A (0.35) | AKR1B1CYP3A4CYP2C9CYP2C19PSEN1 | |
| SCHEMBL14979839 | 0.75 | POLB (0.36) | ACLYCYP2C19PSEN1PSEN2APH1B | |
| SCHEMBL13705599 | 0.74 | AKR1B1 (0.33) | ACLYAKR1B1BRAF | |
| SCHEMBL913409 | 0.72 | CYP3A4 (0.52) | METAP2CYP3A4CYP2C9CYP2C19BRAF | |
| SCHEMBL1490930 | 0.72 | ALDH1A1 (0.39) | CYP3A4CYP2C9CYP2C19ALDH1A1KMT2A | |
| SCHEMBL1437281 | 0.72 | AKR1B1 (0.37) | AKR1B1CYP3A4CYP2C9CYP2C19PSEN1 | |
| SCHEMBL27101468 | 0.70 | BRAF (0.33) | CYP3A4CYP2C9CYP2C19PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111277-A9 | IMIDAZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009111277-A1 | IMDIZO [4. 5-B] PYRIDINE DERIVATIVES USED AS RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |