Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11155054 | 0.84 | CYP3A4 (0.58) | MAPTMEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL9323577 | 0.83 | MAPT (0.52) | MAPTMEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL6882217 | 0.83 | F2 (0.37) | MAPTMEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL6882223 | 0.83 | KDM4E (0.49) | MAPTMEN1KMT2ACYP3A4TDP1 | |
| Benzamide SCHEMBL27820629 | 0.81 | MAPT (0.57) | MAPTMEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL20852547 | 0.81 | PARP1 (0.53) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL547365 | 0.81 | ALDH1A1 (0.62) | MAPTMEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL4576240 | 0.81 | MEN1 (0.54) | MAPTMEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL2705483 | 0.81 | MEN1 (0.54) | MAPTMEN1KMT2ACYP3A4TDP1 | |
| SCHEMBL11216066 | 0.79 | MEN1 (0.62) | MAPTMEN1KMT2ACYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1072644-C | 4-fluoroalkyl substituted phenacyl guanidine, its preparing method, application as medicine or diagnosis agent and medicine containing such compound | HOECHST AG (DE) | 2001-10-10 | — | — | CN | disclosed |
| WO-2000009116-A1 | GRP RECEPTOR LIGANDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-24 | — | — | WO | disclosed |
| CN-1143076-A | 4-fluoroalkyl substituted phenacyl guanidine, its preparing method, application as medicine or diagnosis agent and medicine containing such compound | HOECHST AG (DE) | 1997-02-19 | — | — | CN | disclosed |
| US-5376685-A | Arylhydrazones using as SAMDC inhibitors | CIBA-GEIGY CORPORATION (US) | 1994-12-27 | — | — | US | disclosed |
| US-5238941-A | S-adenosylmethionine decarboxylase inhibitors | CIBA-GEIGY CORPORATION (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0335832-B1 | ARYL HYDRAZONES | CIBA-GEIGY AG (CH) | 1993-02-10 | — | — | EP | disclosed |
| US-5118709-A | Decarboxylase enzyme inhibitors; antitumor agents | CIBA-GEIGY CORPORATION (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971986-A | ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0335832-A2 | Aryl hydrazones | CIBA-GEIGY AG (CH) | 1989-10-04 | — | — | EP | disclosed |