Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.49 |
| ▸ | MASP2 | O00187 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882217 | 0.85 | F2 (0.37) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL8003077 | 0.83 | MAPT (0.54) | KDM4EMAPTHIF1AF2MEN1 | |
| Hydrochloric Acid SCHEMBL11404950 | 0.82 | MAPT (0.46) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL8727227 | 0.76 | F2 (0.36) | MAPTPLAUF2PRSS1PRSS3 | |
| SCHEMBL11365527 | 0.75 | MAPT (0.56) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Bromide SCHEMBL11646455 | 0.75 | MEN1 (0.49) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL27357774 | 0.74 | MAPT (0.41) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL20852547 | 0.73 | PARP1 (0.53) | KDM4EMAPTF2MEN1KMT2A | |
| SCHEMBL7238392 | 0.72 | USP5 (0.44) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL6876467 | 0.71 | LMNA (0.53) | KDM4EMAPTHIF1ASLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-B1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR INC (US) | 2004-01-14 | — | — | EP | disclosed |
| CN-1190401-A | C-4' modified adenosine kinase inhibitors | GENSIA INC (US) | 1998-08-12 | — | — | CN | disclosed |