Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.33 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13750944 | 0.96 | PDE4B (0.43) | PDE4BMAPK1CHRM2CHRM1CHRM3 | |
| SCHEMBL4099149 | 0.94 | PDE4B (0.46) | PDE4BMAPK1CHRM2CHRM1CHRM3 | |
| SCHEMBL3429059 | 0.94 | PDE4B (0.49) | PDE4BMAPK1PDE7A | |
| SCHEMBL8007729 | 0.93 | PDE4B (0.44) | PDE4BMAPK1CHRM2CHRM1CHRM3 | |
| SCHEMBL8002791 | 0.93 | PDE4B (0.44) | PDE4BMAPK1CHRM2CHRM1CHRM3 | |
| SCHEMBL8011054 | 0.93 | PDE4B (0.45) | PDE4BMAPK1 | |
| SCHEMBL8002739 | 0.92 | PDE4B (0.43) | PDE4BMAPK1CHRM2CHRM1CHRM3 | |
| SCHEMBL13750940 | 0.90 | PDE4B (0.47) | PDE4BMAPK1CHRM2CHRM1CHRM3 | |
| SCHEMBL3426907 | 0.90 | PDE4B (0.41) | PDE4BMAPK1CHRM2CHRM1CHRM3 | |
| SCHEMBL13750943 | 0.89 | PDE4B (0.43) | PDE4BMAPK1CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |