SCHEMBL8004774

SCHEMBL8004774

CN(C)CCN(Cc1ccc(C(=O)Nc2cscc2N)nc1)C(=O)Nc1ccc(O)c(O)c1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 6/20 0.45
ROCK1 Q13464 6/20 0.37
HDAC1 Q13547 7/20 0.37
HDAC2 Q92769 6/20 0.37
HDAC3 O15379 6/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CDC42BPA Q5VT25 1/20 0.37
NCOR2 Q9Y618 2/20 0.36
PDCD1 Q15116 1/20 0.35
CD274 Q9NZQ7 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11892998 0.95 ROCK2 (0.42) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL1497046 0.89 ROCK2 (0.46) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL8002177 0.88 ROCK2 (0.50) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL1482300 0.88 ROCK2 (0.41) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL1496895 0.87 ROCK2 (0.45) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL1496974 0.87 MEN1 (0.43) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL1497119 0.86 ROCK2 (0.42) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL1497129 0.86 ROCK2 (0.42) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL1496890 0.86 ROCK2 (0.49) ROCK2ROCK1HDAC1HDAC2HDAC3
SCHEMBL1496998 0.86 RAB9A (0.42) ROCK2HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009142321-A1 NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE 参天製薬株式会社 (JP) 2009-11-26 WO disclosed