Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 9/20 | 0.59 |
| ▸ | PDE4A | P27815 | 14/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990332 | 0.94 | PDE4A (0.58) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8002258 | 0.88 | PDE4A (0.56) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL562472 | 0.85 | PDE4A (0.69) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8000339 | 0.82 | ADORA2A (0.54) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1460898 | 0.81 | PDE4A (0.75) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9032157 | 0.81 | PDE4A (0.75) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1460888 | 0.75 | ADORA2A (0.55) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7998620 | 0.75 | ADORA2A (0.42) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9791629 | 0.75 | PDE4A (0.89) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7738354 | 0.74 | ADORA2B (1.00) | ADORA2BPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294541-B1 | ENZYME INHIBITORS USING PURINE COMPOUNDS AS ANTIHISTAMINES | EURO-CELTIQUE S.A. (LU) | 2001-09-25 | — | — | US | claimed |
| EP-0916673-A1 | 6-Amino purine derivatives having PDE-IV inhibition activity | Euroceltique S.A. (LU) | 1999-05-19 | — | — | EP | disclosed |
| EP-0916672-A1 | 6-Amino purine derivatives having PDE-IV inhibition activity and intermediates | Euroceltique S.A. (LU) | 1999-05-19 | — | — | EP | disclosed |