Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.49 |
| ▸ | HTR2B | P41595 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005382 | 1.00 | HTR2C (0.49) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL11042270 | 0.80 | SLC6A4 (0.65) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL16356787 | 0.80 | SLC6A4 (0.65) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL16356786 | 0.80 | SLC6A4 (0.65) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL8005384 | 0.77 | HTR2C (0.49) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL1289737 | 0.74 | SLC6A4 (0.67) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL7969639 | 0.72 | ALOX5 (0.53) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL7969636 | 0.72 | ALOX5 (0.53) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL13807755 | 0.72 | MAOA (0.45) | HTR2CHTR2BHTR2AMAOBSLC6A4 | |
| SCHEMBL12511292 | 0.72 | MAOA (0.45) | HTR2CHTR2BHTR2AMAOBSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000021910-A2 | 1,2-DISUBSTITUTED CYCLOPROPANES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-04-20 | — | — | WO | disclosed |