SCHEMBL8005449

SCHEMBL8005449

CS(=O)(=O)c1cc(C=O)ccc1Oc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.61
KMT2A Q03164 5/20 0.44
LMNA P02545 3/20 0.44
GAA P10253 1/20 0.44
PTGS2 P35354 1/20 0.42
HPGD P15428 2/20 0.41
ALDH1A1 P00352 5/20 0.41
TSHR P16473 1/20 0.41
CASP1 P29466 1/20 0.40
POLB P06746 4/20 0.39
MEN1 O00255 4/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
RXFP1 Q9HBX9 2/20 0.39
AOX1 Q06278 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
APEX1 P27695 1/20 0.38
MAPT P10636 2/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18993645 0.85 TTR (0.57) TTRKMT2ALMNAGAAALDH1A1
SCHEMBL5892840 0.81 TTR (0.45) TTRKMT2ALMNAGAAPTGS2
SCHEMBL11795573 0.79 TTR (0.81) TTRKMT2ALMNAGAAHPGD
SCHEMBL29446607 0.79 TTR (0.81) TTRKMT2ALMNAGAAHPGD
SCHEMBL29181894 0.78 MEN1 (0.58) TTRKMT2ALMNAALDH1A1POLB
SCHEMBL29625906 0.78 BRD4 (0.46) KMT2APTGS2POLBMEN1SMN1; SMN2
SCHEMBL28738313 0.78 BRD4 (0.46) KMT2APTGS2POLBMEN1SMN1; SMN2
SCHEMBL8498710 0.78 TTR (0.69) TTRKMT2ALMNAGAAALDH1A1
SCHEMBL2592579 0.76 TTR (0.88) TTRKMT2ALMNAGAAHPGD
SCHEMBL1616189 0.76 TTR (1.00) TTRHPGDALDH1A1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6022899-A EFFECTIVE INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER HOECHST AKTIENGESELLSCHAFT (DE) 2000-02-08 US disclosed
US-5753710-A INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER HOECHST AKTIENGESELLSCHAFT (DE) 1998-05-19 US disclosed
EP-0748795-A2 Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them HOECHST AKTIENGESELLSCHAFT (DE) 1996-12-18 EP disclosed