Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | SHBG | P04278 | 4/20 | 0.48 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.48 |
| ▸ | PGR | P06401 | 4/20 | 0.48 |
| ▸ | AR | P10275 | 3/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11496789 | 0.79 | CYP3A4 (0.53) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7755258 | 0.77 | SRD5A1 (0.46) | AR | |
| SCHEMBL8894380 | 0.77 | SRD5A1 (0.46) | AR | |
| SCHEMBL8804307 | 0.75 | LMNA (0.81) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23748331 | 0.71 | CYP3A4 (0.71) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11152503 | 0.71 | CYP19A1 (0.65) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9640298 | 0.71 | SMN1; SMN2 (0.71) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6053061 | 0.71 | CYP19A1 (0.66) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL674222 | 0.71 | CYP3A4 (0.71) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9528950 | 0.71 | ALDH1A1 (0.58) | LMNACYP3A4ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858455-A4 | 4-OXA AND 4-THIA STEROIDS | MERCK & CO INC (US) | 2000-04-12 | — | — | EP | disclosed |
| US-5998464-A | 4-Oxa and 4-thia steroids | MERCK & CO., INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5932559-A | Treatment of hyperandrogenic conditions | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0858455-A1 | 4-OXA AND 4-THIA STEROIDS | Merck & Co., Inc. (US) | 1998-08-19 | — | — | EP | disclosed |
| US-5777134-A | 4-oxa and 4-thia steriods | MERCK & CO., INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5756480-A | Treatment of hyperandrogenic conditions | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |
| WO-1997015305-A1 | TREATMENT OF HYPERANDROGENIC CONDITIONS | MERCK & CO., INC. (US) | 1997-05-01 | — | — | WO | disclosed |
| WO-1997015564-A1 | 4-OXA AND 4-THIA STEROIDS | MERCK & CO., INC. (US) | 1997-05-01 | — | — | WO | disclosed |