Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 14/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691774 | 0.98 | TSHR (0.36) | PTGS1PTGS2KMT2AOPRK1HTT | |
| SCHEMBL19006033 | 0.78 | KDM4E (0.30) | KDM4EALDH1A1 | |
| SCHEMBL22289913 | 0.69 | GFER (0.46) | KMT2AHCAR2TSHRGFERKDM4E | |
| SCHEMBL20842318 | 0.67 | KMT2A (0.48) | PTGS1PTGS2KMT2ATSHRKDM4E | |
| SCHEMBL299539 | 0.67 | BCL2L1 (0.46) | PTGS2KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL2114253 | 0.66 | KDM4E (0.45) | KMT2AHCAR2TSHRGFERKDM4E | |
| SCHEMBL7817311 | 0.65 | ALOX15 (0.33) | SMN1; SMN2 | |
| SCHEMBL1173794 | 0.65 | NOTUM (0.45) | PTGS1PTGS2TSHR | |
| SCHEMBL4789593 | 0.65 | HSD17B10 (0.47) | KMT2AHCAR2TSHRGFERKDM4E | |
| SCHEMBL19140344 | 0.64 | USP2 (0.45) | KMT2AHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |