Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 14/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005765 | 0.98 | PTGS1 (0.35) | TSHRPTGS1PTGS2KMT2AOPRK1 | |
| SCHEMBL19006033 | 0.77 | KDM4E (0.30) | KDM4EALDH1A1 | |
| SCHEMBL22289913 | 0.68 | GFER (0.46) | TSHRKMT2AHCAR2GFERKDM4E | |
| SCHEMBL25873389 | 0.67 | TSHR (0.32) | TSHRSMN1; SMN2 | |
| SCHEMBL20842318 | 0.66 | KMT2A (0.48) | TSHRPTGS1PTGS2KMT2AKDM4E | |
| SCHEMBL299539 | 0.66 | BCL2L1 (0.46) | PTGS2KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL6691776 | 0.65 | NPSR1 (0.41) | TSHRKMT2AHCAR2KDM4EMEN1 | |
| SCHEMBL2114253 | 0.65 | KDM4E (0.45) | TSHRKMT2AHCAR2GFERKDM4E | |
| SCHEMBL7817311 | 0.64 | ALOX15 (0.33) | SMN1; SMN2 | |
| SCHEMBL1173794 | 0.64 | NOTUM (0.45) | TSHRPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040186160-A1 | Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors | SUGEN, INC. | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186160-A1 | Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors | MAP3K15, MAP3K20, MAP3K19 | TSHR 2444/4885PTGS1 1355/4885PTGS2 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.