Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | USP5 | P45974 | 1/20 | 0.31 |
| ▸ | USP14 | P54578 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | ARG2 | P78540 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL303937 | 0.89 | ALDH1A1 (0.34) | KDM4EALDH1A1USP2SMN1; SMN2MAPK1 | |
| SCHEMBL303939 | 0.89 | ALDH1A1 (0.34) | KDM4EALDH1A1USP2SMN1; SMN2MAPK1 | |
| SCHEMBL800059 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1965586 | 0.77 | SMN1; SMN2 (0.45) | KDM4EALDH1A1USP2SMN1; SMN2MAPK1 | |
| SCHEMBL12640379 | 0.74 | ALDH1A1 (0.41) | KDM4EALDH1A1USP2SMN1; SMN2TERT | |
| SCHEMBL10193628 | 0.72 | ALDH1A1 (0.36) | KDM4EALDH1A1USP2SMN1; SMN2TERT | |
| SCHEMBL304459 | 0.71 | ALDH1A1 (0.35) | KDM4EALDH1A1USP2SMN1; SMN2TERT | |
| SCHEMBL304457 | 0.71 | ALDH1A1 (0.35) | KDM4EALDH1A1USP2SMN1; SMN2TERT | |
| SCHEMBL303938 | 0.71 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2TERT | |
| SCHEMBL304458 | 0.70 | USP2 (0.35) | ALDH1A1USP2TERTUSP5USP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160151322-A1 | METALLO-B-LACTAMASE INHIBITORS | MEIJI SEIKA KAISHA (JP) | 2016-06-02 | — | — | US | disclosed |
| US-9260375-B2 | Metallo-β-lactamase inhibitors | MEIJI SEIKA KAISHA, LTD. (JP) | 2016-02-16 | — | — | US | disclosed |
| US-20120071457-A1 | METALLO-BETA-LACTAMASE INHIBITORS | CHIKAUCHI KEN (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071457-A1 | METALLO-BETA-LACTAMASE INHIBITORS | ME1, MGAM, GAA | KDM4E 2771/4885ALDH1A1 372/4885USP2 1517/4885 |
| US-20160151322-A1 | METALLO-B-LACTAMASE INHIBITORS | ME1, MGAM, MANBA | KDM4E 2768/4885ALDH1A1 461/4885USP2 1671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.