SCHEMBL8006014

SCHEMBL8006014

CCC[SiH]1CCC([C@H]2CC[C@H](CCc3ccc(-c4ccc(F)c(F)c4)cc3)CC2)CC1

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
RARB P10826 2/20 0.34
RARA P10276 1/20 0.34
RARG P13631 1/20 0.34
GPR84 Q9NQS5 1/20 0.33
MAOB P27338 2/20 0.32
MAOA P21397 1/20 0.32
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7756524 1.00 CYP17A1 (0.34) CYP17A1CYP11B1CYP11B2RARBRARA
SCHEMBL8006018 1.00 CYP17A1 (0.34) CYP17A1CYP11B1CYP11B2RARBRARA
SCHEMBL8021369 0.93 CYP17A1 (0.37) CYP17A1CYP11B1CYP11B2RARBRARA
SCHEMBL8021366 0.93 CYP17A1 (0.37) CYP17A1CYP11B1CYP11B2RARBRARA
SCHEMBL8017804 0.92 RARB (0.39) CYP17A1CYP11B1CYP11B2RARBRARA
SCHEMBL8017802 0.92 RARB (0.39) CYP17A1CYP11B1CYP11B2RARBRARA
SCHEMBL7759062 0.92 RARB (0.39) CYP17A1CYP11B1CYP11B2RARBRARA
SCHEMBL8022276 0.91 GPR84 (0.33) RARBRARARARGGPR84MAOB
SCHEMBL8022275 0.91 GPR84 (0.33) RARBRARARARGGPR84MAOB
SCHEMBL8015923 0.91 SLC6A2 (0.34) MAOBMAOASLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8048689-A None JP disclosed
EP-0670322-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 2000-01-19 EP disclosed
EP-0692485-B1 Cyclohexane carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde compound SHINETSU CHEMICAL CO (JP) 2000-01-05 EP disclosed
US-5762826-A Liquid crystal composition and a liquid crystal display element which contains it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-06-09 US disclosed
US-5582764-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-12-10 US disclosed
US-5519156-A Cyclohexane carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-05-21 US disclosed
JP-H0848689-A SILACYCLOHEXANE COMPOUND, ITS PRODUCTION AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME COMPOUND SHIN ETSU CHEM CO LTD 1996-02-20 JP disclosed
EP-0692485-A1 Cyclohexane carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde compound Shin-Etsu Chemical Co., Ltd. (JP) 1996-01-17 EP disclosed
EP-0670322-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-09-06 EP disclosed