Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7401568 | 0.90 | CARM1 (0.41) | MEN1LMNACYP2C9PMP22KMT2A | |
| Maleic Acid SCHEMBL7398561 | 0.88 | MEN1 (0.37) | MEN1LMNACYP3A4CYP2C9PMP22 | |
| Fumaric Acid SCHEMBL7398568 | 0.88 | MEN1 (0.37) | MEN1LMNACYP3A4CYP2C9PMP22 | |
| Maleic Acid SCHEMBL8015447 | 0.86 | CARM1 (0.38) | MEN1LMNAPMP22KMT2ACARM1 | |
| SCHEMBL7397138 | 0.83 | CYP2C9 (0.39) | MEN1LMNACYP3A4CYP2C9PMP22 | |
| Maleic Acid SCHEMBL8016002 | 0.82 | CARM1 (0.40) | MEN1LMNACYP2C9PMP22KMT2A | |
| Maleic Acid SCHEMBL8018622 | 0.82 | CARM1 (0.39) | MEN1LMNACYP2C9PMP22KMT2A | |
| SCHEMBL8123035 | 0.80 | CHRM3 (0.39) | CARM1PRMT6CHRM3 | |
| Maleic Acid SCHEMBL8006649 | 0.79 | KDM1A (0.38) | LMNAPMP22KMT2AACKR3CARM1 | |
| Hydrochloric Acid SCHEMBL8122956 | 0.77 | CARM1 (0.41) | MEN1CYP2C9PMP22KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972773-A1 | 2-Oxadiazolyl- or 2-thiadiazolyl-phenylcarbamate and -phenylurea derivatives, their preparation and their use as intermediates | GLAXO GROUP LIMITED (GB) | 2000-01-19 | — | — | EP | disclosed |
| EP-0640081-B1 | SUBSTITUTED PHENYLCARBAMATES AND PHENYLUREAS, THEIR PREPARATION AND THEIR USE AS 5-HT4 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2000-01-12 | — | — | EP | disclosed |