Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10749706 | 0.84 | MME (0.49) | MMEACECPA1ACE2CTNNB1 | |
| SCHEMBL10389860 | 0.83 | CTNNB1 (0.50) | MMEACECPA1ACE2CTNNB1 | |
| SCHEMBL7297927 | 0.83 | CTNNB1 (0.50) | MMEACECPA1ACE2CTNNB1 | |
| SCHEMBL9665093 | 0.83 | CTNNB1 (0.50) | MMEACECPA1ACE2CTNNB1 | |
| SCHEMBL10520573 | 0.82 | MEN1 (0.53) | CTNNB1MAPTHRH4MMP2MMP9 | |
| SCHEMBL7288450 | 0.81 | EPHX1 (0.47) | MMEACECPA1ACE2CTNNB1 | |
| SCHEMBL10338654 | 0.81 | CPA1 (0.57) | MMEACECPA1ACE2CTNNB1 | |
| SCHEMBL7429100 | 0.81 | CPA1 (0.57) | MMEACECPA1ACE2CTNNB1 | |
| SCHEMBL9194477 | 0.81 | CPA1 (0.57) | MMEACECPA1ACE2CTNNB1 | |
| SCHEMBL10519718 | 0.81 | HRH4 (0.52) | CPA1CTNNB1MAPTHRH4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1059433-C | New arylalkyl (thio) carboxamides, processes for preparing them and pharmacetuical compositions containing them | ADIR (FR) | 2000-12-13 | — | — | CN | claimed |
| EP-0745584-B1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-01-05 | — | — | EP | claimed |
| US-5721276-A | TREATING DISORDERS OF MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-02-24 | — | — | US | claimed |
| CN-1145894-A | New arylalkyl (thio) carboxamides, processes for preparing them and pharmacetuical compositions containing them | ADIR (FR) | 1997-03-26 | — | — | CN | claimed |
| EP-0745584-A1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | claimed |
| CN-1059433-C | New arylalkyl (thio) carboxamides, processes for preparing them and pharmacetuical compositions containing them | ADIR (FR) | 2000-12-13 | — | — | CN | disclosed |
| EP-0745584-B1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-01-05 | — | — | EP | disclosed |
| US-5721276-A | TREATING DISORDERS OF MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-02-24 | — | — | US | disclosed |
| CN-1145894-A | New arylalkyl (thio) carboxamides, processes for preparing them and pharmacetuical compositions containing them | ADIR (FR) | 1997-03-26 | — | — | CN | disclosed |
| EP-0745584-A1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |
| EP-0745584-A1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |