Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10749706 | 0.84 | MME (0.49) | CTNNB1HRH4MMP2MMP9MMP8 | |
| SCHEMBL10338654 | 0.83 | CPA1 (0.57) | CTNNB1HRH4HPGDTDP1 | |
| SCHEMBL7429100 | 0.83 | CPA1 (0.57) | CTNNB1HRH4HPGDTDP1 | |
| SCHEMBL9194477 | 0.83 | CPA1 (0.57) | CTNNB1HRH4HPGDTDP1 | |
| SCHEMBL10519718 | 0.83 | HRH4 (0.52) | MEN1KMT2AMAPTCTNNB1HRH4 | |
| SCHEMBL7291238 | 0.83 | HRH4 (0.52) | MEN1KMT2AMAPTCTNNB1HRH4 | |
| SCHEMBL6677809 | 0.82 | CTNNB1 (0.63) | MEN1KMT2AMAPTCTNNB1HRH4 | |
| SCHEMBL8006913 | 0.82 | MME (0.47) | MEN1KMT2AMAPTCTNNB1HRH4 | |
| Hydrochloric Acid SCHEMBL10338415 | 0.81 | CPA1 (0.56) | CTNNB1HRH4HPGDTDP1 | |
| Hydrochloric Acid SCHEMBL10338413 | 0.81 | CPA1 (0.56) | CTNNB1HRH4HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |